本研究評估了低嵌合體水平(< 50%)胚胎的潛在活力。

本研究評估了低嵌合體水平(< 50%)胚胎的潛在活力。
研究表明嵌合胚胎可以發育成具有不同水平或類型嵌合體的整倍體健康嬰兒。
整倍體和嵌合囊胚移植的嬰兒之間沒有觀察到顯著差異。
如果患者沒有整倍體胚胎,則可以移植嵌合胚胎,它們有可能植入並發育成整倍體健康嬰兒。
這項研究對於諮詢單一嵌合胚胎移植後的臨床結果非常有價值。
J Assist Reprod Genet
. 2020 Sep;37(9):2305-2313. doi: 10.1007/s10815-020-01876-6. Epub 2020 Jul 4.Healthy live births from transfer of low-mosaicism embryos after preimplantation genetic testing for aneuploidy
This study evaluated the potential viability of embryos with low mosaicism level (< 50%) by comparing the clinical outcomes of single mosaic versus euploid blastocyst transfer.  
Our study indicated that mosaic embryos can develop into euploid healthy infants with various levels or types of mosaicism. 
No significant difference was observed between infants from euploid and mosaic blastocyst transfers.
If patients have no euploid embryos, mosaic embryos can be transferred as they have potential for implantation and development into euploid healthy infants. 
This study is invaluable for counseling clinical results after single mosaic embryo transfers.
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